Healthy, non-smoking males and females, age 18-40, are needed for studies on how changes in muscle temperature effect histamine in the muscle. Subjects can be “sedentary” or “recreationally active”, but not engaging in more than 5 hours of exercise a week. Subjects must not be on any medications (oral contraceptives acceptable), must not be taking herbal remedies or dietary supplements, and cannot be pregnant or currently breast-feeding. Subjects may not be using illegal/recreational drugs. Subjects must not have had prior allergic reactions to drugs or medication, specifically histamine receptor blockers (e.g. fexofenadine/Allegra, ranitidine/Zantac) and not be currently taking non-steroidal anti-inflammatory medications (NSAIDs). Subjects will be excluded if they have a pacemaker and/or if they have had a surgery below the mid-section. Participants will not be allowed to participate in vigorous exercise before and one week after the study. The study lasts approximately 7 hours spread over 2 visits. This study is being conducted in the Department of Human Physiology at the University of Oregon. This study is sponsored by the National Institute of Health. Subjects will be compensated for their participation in this study.
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